Tosyl ester(s) of α-hydroxy acid(s) – Synthesis and antimicrobial studies

Authors

  • R. Kavitha PG & Research Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli – 620 019, Tamil Nadu, India
  • S. Ananthalakshmi PG & Research Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli – 620 019, Tamil Nadu, India

Keywords:

Tosyl esters, α-hydroxy acids, Sulfonyl sulfur, TLC technique, Antimicrobial activity, Agar well diffusion method

Abstract

Tosyl ester(s) of α-hydroxy acid(s) were prepared by treating the acid with p-toluenesulfonyl chloride (TsCl) in the presence of pyridine. The products were isolated, identified by TLC and characterized by IR, 1H-NMR and 13C-NMR spectral techniques. Anti microbial activity of the synthesized compounds were studied by Agar well diffusion method against two bacterial (Escherichia Coli and Staphylococus Aureus) and two fungal (Candida albicans and Aspergillus Niger) species using Ciprofloxacin against the bacterial strains, Nystatin against Candida albicans and Amphotericin against Aspergillus niger as standard antibiotics. The results infer that the tosyl ester(s) of α- hydroxy acid(s) are potentially active against bacterial and fungal strains.

 

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Published

2018-08-30

How to Cite

[1]
R. Kavitha and S. Ananthalakshmi, “Tosyl ester(s) of α-hydroxy acid(s) – Synthesis and antimicrobial studies”, Int. J. Sci. Res. Biol. Sci., vol. 5, no. 4, pp. 61–65, Aug. 2018.

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Research Article

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