Antifungal activity of Salacia oblonga extracts Against Human Pathogen Candida albicans

Authors

  • Anjaneyulu Musini Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, India
  • Bhargavi Pokala Souq Waqif Falcon Hospital Research and diagnostic Laboratory, Souq Waqif , Doha, Qatar
  • Zahoorullah.S. MD Atal Incubation Centre, ALEAP WEHUB, ALEAP Industrial Estate, Gajularamaram, Hyderabad, India
  • Prathima Yeddanapalli Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, India
  • Jahnavi Manchella Centre for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, India

Keywords:

Salacia oblonga, Antifungal activity, Candida albicans, Chromatography

Abstract

Salacia Oblonga shrub belonging to the family ‘Celestraceae’. It is found in India and Srilanka. We have collected the plant extract from Western Ghats, India. In traditional medicines it is used for the treatment of diabetes and can be exploited to treat many chronic and infectious diseases. The plant extracts of S.oblonga has been used on the treatment of diabetes, polyuria, gonorrhea, rheumatism, asthma and fever. We have undertaken present study to evaluate the antifungal activity of S.oblonga aerial and root extracts against human pathogen Candida albicans. Antifungal activity of methanol extract (1 mg/ml) and ethyl acetate extracts were tested. Extracts have shown good growth inhibition against Candida albicans. Identified the minimum inhibitory concentration of the plant extract 40µg/ml comparison with synthetic drug Clotrimazole 60µg/ml. Separation of the phytochemical from the crude extracts by thin layer chromatography and identified the active fraction. Our study highlighted the antifungal activity of Salacia Oblonga extracts.

 

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Published

2018-12-31

How to Cite

[1]
A. Musini, B. Pokala, Z. MD, P. Yeddanapalli, and J. Manchella, “Antifungal activity of Salacia oblonga extracts Against Human Pathogen Candida albicans”, Int. J. Sci. Res. Biol. Sci., vol. 5, no. 6, pp. 220–223, Dec. 2018.

Issue

Vol. 5 No. 6 (2018): December Edition

Section

Research Article

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