Toxicological profile of synthetic pyrethroid type II fenvalerate in chicks
Keywords:
Synthetic pyrethroid, Fenvalerate, chronic exposure, toxicity, biochemical, heamatological changes, Gallus domesticusAbstract
Sub acute toxicity of oral administration of fenvalerate in chicks was assessed. Birds were divided into seven groups with each group containing 20 birds. The birds of group C1 was given no treatment and served as control. Group C2 was administered groundnut oil and served as vehicle. Group T1, T2, T3, T4, T5 were given 3mg/kg bw of fenvalerate suspended in groundnut oil for 5, 10, 15, 20, 25 days daily. The blood sample were collected from birds after oral administration of fenvalerate and analyzed for hematological and biochemical parameters. The study showed that haematological parameter Hemoglobin, packed cell volume, total erythrocyte count remained unaffected while total leukocyte count was decreased significantly. Fenvalerate induced significant elevation in serum aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) was observed in treatment groups however serum total protein decreased in all treated groups while serum glucose and cholesterol show significant increase as compare to controls throughout the study. It is concluded that chronic exposure of low dose of fenvalerate leads to significant biochemical and haematological changes and cause adverse effect on metabolism of birds.
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