Comparison and Prediction of toxicity parameters of principal Aflatoxins, antimicrobial compounds and Antifungal Drugs by pKCSM server

Authors

  • I.V. Ferrari Dept. of Industrial Engineering, University of Rome Tor Vergata, Rome, Italy
  • M. Di Mario Dept. of Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy

Keywords:

pKCSM server, Aflatoxins, Antifungal Drugs

Abstract

The purpose of this short study is to estimate the main toxicity properties of main Aflatoxins, Antimicrobial bio- compounds and Antifungal Drugs by pKCSM server. Several tests are performed, for instance AMES toxicity; Max. tolerated dose (human) (log mg/kg/day in units); Oral Rat Acute Toxicity (LD50) (mol/kg in units) Oral Rat Chronic Toxicity (LOAEL); Log mg/kg_bw/day in units);Hepatotoxicity; Skin Sensitisation; Pyriformis toxicity (log µg/L)and Minnow toxicity (log mM in units).

 

References

Wogan, Gerald N. "Chemical nature and biological effects of the aflatoxins." Bacteriological reviews, Vol. 30. Issue.2, pp.460-470, 1966.

Asao, Toyonobu, et al. "Aflatoxins b and g." Journal of the American Chemical Society, Vol.85, Issue.11, pp.1706-1707,1963.

Smith, J. E. "Aflatoxins." Handbook of plant and fungal toxicants. CRC Press pp. 269-285, 2020.

Khlangwiset, Pornsri, Gordon S. Shephard, and Felicia Wu. "Aflatoxins and growth impairment: a review." Critical reviews in toxicology, Vol.41,Issue.9, 740-755, 2011.

Guengerich, F. Peter, et al. "Activation and detoxication of aflatoxin B1." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol.402, Issue.1-2, pp.121-128,1998.

Razzaghi-Abyaneh, Mehdi, et al. "Dillapiol and apiol as specific inhibitors of the biosynthesis of aflatoxin G1 in Aspergillus parasiticus." Bioscience, biotechnology, and biochemistry, Vol.71,Issue.9, pp. 2329-2332, 2007.

Prandini, Aldo, et al. "On the occurrence of aflatoxin M1 in milk and dairy products." Food and chemical toxicology, Vol.47, Issue.5,pp. 984-991, 2009.

Kraus, George A., and Xuemei Wang. "A direct synthesis of aflatoxin M2." Tetrahedron letters, Vol.40, Issue.49 pp. 8513-8514, 1999.

Trucksess, M. W., et al. "Aflatoxicol and aflatoxins B1 and M1 in eggs and tissues of laying hens consuming aflatoxin-contaminated feed." Poultry Science, Vol.62,Issue.11, pp.2176-2182,1983.

Masri, M. Sid, et al. "Aflatoxin Q1. Newly identified major metabolite of aflatoxin B1 in monkey liver." Journal of agricultural and food chemistry, Vol.22, Issue.3, pp. 512-515,1974.

Arduini, Fabiana, et al. "Biosensors based on cholinesterase inhibition for insecticides, nerve agents and aflatoxin B 1 detection." Microchimica Acta, Vol.170, Issue.3-4, pp.193-214,2010.

Arduini, Fabiana, et al. "Enzymatic spectrophotometric method for aflatoxin B detection based on acetylcholinesterase inhibition." Analytical Chemistry, Vol.79, Issue.9, pp.3409-3415, 2007.

Elizalde-González, Mar??a P., Jürgen Mattusch, and Rainer Wennrich. "Stability and determination of aflatoxins by high-performance liquid chromatography with amperometric detection." Journal of Chromatography A, Vol. 828,Issue.1-2,pp. 439-444,1998.

Holcomb, M., et al. "Determination of aflatoxins in food products by chromatography." Journal of Chromatography A, Vol. 624, Issue.1-2, 341-352,1992.

Sibanda, Liberty, Sarah De Saeger, and Carlos Van Peteghem. "Development of a portable field immunoassay for the detection of aflatoxin M1 in milk." International journal of food microbiology,Vol. 48,Issue.3, pp.203-209, 1999.

Duchowicz, Pablo R., et al. "Application of descriptors based on Lipinski’s rules in the QSPR study of aqueous solubilities." Bioorganic & medicinal chemistry, Vol. 15, Issue.11, pp. 3711-3719, 2007.

Pires, Douglas EV, Tom L. Blundell, and David B. Ascher. "pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures." Journal of medicinal chemistry, Vol. 58, Issue.9, pp. 4066-4072, 2015.

Hampannavar, Girish A., et al. "An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG)." Bioorganic & medicinal chemistry, Vol. 24, Issue.4, pp.501-520, 2016.

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Published

2022-02-28

How to Cite

[1]
I. Ferrari and M. D. Mario, “Comparison and Prediction of toxicity parameters of principal Aflatoxins, antimicrobial compounds and Antifungal Drugs by pKCSM server”, Int. J. Sci. Res. Biol. Sci., vol. 9, no. 1, pp. 48–52, Feb. 2022.

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Research Article

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