Investigation of Carmofur-Derived Growth Supression in Lung Cancer Cell
Keywords:
Carmofur, Lung cancer, Apoptosis, Cancer treatment, CytotoxicityAbstract
Lung cancer is a malignant form of uncontrolled cell growth in lung tissues with high incidence of mortality in the world. Despite the rise in survival ratios in recent five years lung cancer patients survived relatively poor because of the treatment limitations. Chemotherapeutics have biggest handicap in their usage for cancer treatment that cancer cells develop resistance to them. Herein, carmofur, a form of pyrimidine analogue was used for stimulating cell death in lung cancer cells based on its anti-proliferative potency in many cancer cells. Cytotoxic activity was tested via MTT assay. In addition, ultrastructural and morphological changes were evaluated via transmission and confocal microscopies. The IC50 value was determined to be 23 µM for 24 hours. Morphological and ultrastructural analyses imply to clear apoptosis. Consecutively, carmofur might be suggested for deeper examinations in the manner of improvement of the apoptosis triggering potency for designing a florouracil-derived permanent antineoplastic agent.
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