Handling a Novel Nanoscale D-erythro-MAPP in Lung Cancer Treatment: An In vitro Cytotoxicity Research
Keywords:
A549, D-e-MAPP, Sphingolipid, Solid Lipid Nanoparticles, CeramidaseAbstract
Cancer disease cause high mortality rates through the world. Lung cancer has ranked between the most prevalent cancers among the rare cancer types. Surgical resection, chemotherapy and radiation are current techniques for its treatment. Besides traditional applications, it is necessary to explore and use more effective and inexpensive agents with low toxicity for lung cancer cure. While sphingolipids are the key bio-active elements of cellular membranes in high organisms, they serve as significant modulators of bio-functions of the cells as proliferation, division and death. Based on the above mentioned regulatory functions of ceramide molecule including with its role as cell signalling agent it has been regarded as a target for anticancer treatment with high potency. The utilization of nano-scale compounds for treatment approaches currently have become popular and initiate the invention of a variety of nano-materials with improved specific characteristics and multi-dimensional theranostic functions. Herein, a novel solid lipid nanoparticle of the ceramidase inhibitor, D-erythro-MAPP (D-e-MAPP), with modified targeting ability was designed, produced, and investigated as potential anticancer agent. Results imply to the high level pro-apoptotic and cytotoxic actions of the agent on lung cancer cells, thus it may be suggested for a high potent candidate for cancer therapy
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