Ambient Air Pollution and Histopathologic Effects of Quarry Industry on Liver and Kidney of Albino Rats
Keywords:
Particulate matter, quarry industry, gaseous pollutants, quarry workers, albino ratsAbstract
The present research studied the histopathologic effects of air pollution in a Quarry industry on the liver and kidney of albino rats. Thirty male albino rats were housed at various locations of the industry in five groups of five rats each for 90 days. Control animals were housed at a distance of 5.7km from the industry. Air sampling was done using gas monitor and analyzer at the same locations as in animal sampling. This was done three times at each point per day, and once a week for 90 days. From the results, levels of NO2 in the quarry ambient air were above the WHO standard values of 0.04-0.06mg/m3. Concentrations of SO2 in the quarry increased significantly compared (p<0.05) to the control and were also above the WHO standard value of 0.01mg/m3. The levels of particulate matter 1 (PM1) in the quarry increased significantly compared (p<0.05) to the control and also higher than the WHO standard value of 0.25µg/m3. The Concentrations of particulate matter 2.5 (PM2.5) in the quarry industry were below the WHO standard value of 10.00µg/m3 except at the crusher with a concentration of 11.40±1.00µg/m3 in the afternoon. Levels of the heavy metals in the dust were significantly higher in the quarry compared (p<0.05) to the control. The values of chromium, arsenic and lead were above the Nigerian Environmental Standard and Regulation Enforcement Agency (NESREA) standard values. Histopathological findings indicate that the albino rats suffered from cholate stasis and nephrosis but rats housed at the drilling pit and crusher sections of the quarry industry were greatly affected. These findings suggest that quarry workers who work without appropriate and effective safety equipments will likely suffer from liver and kidney injury and diseases.
References
M. Khan and M.D. Tarique. “Industrial pollution in Indian industries: A post reform Scenario”. Journal of Environmental Technology Volume 2, issue 2, pp. 182-187, 2015.
F.U. Madu, E.I. Akubugwo, F.O. Uhegbu and K.U. Uzoma. “Assessment of Soil Quality Characteristics and Pollution Status of Farm Lands within Ugwuele Quarry Site, Uturu Abia State Nigeria.” International Journal of Scientific research in Multidisciplinary studies, volume 6, issue 7, pp. 52-59, 2020.
A.Q. Aigbokhaode, E.C. Isah and A.R. Isara. “Knowledge and practice of occupational safety practices among quarry workers in a rural community in Edo state, Nigeria”. Journal of community Health and Primary Health-care, volume, 23, issues 1&2. Pp. 16-24, 2011.
O.C. Ugbogu, J. Ohakwe and V. Foltescu. “Occurrence of respiratory and skin problems among manual stone quarry workers”. African Journal of respiratory medicine, volume 10, pp. 23-26, 2009.
B.S. Bada, K.A. Olatunde and O.A. Akande. “Air quality Assessment in the vicinity of quarry site”. Environment and Natural Resources Research, volume 3, issue 2, pp. 111-116, 2013.
O.K. Kurt, J. Zhang and K.E. Pinkerton. “Pulmonary health effects of air pollution”. Current opinion in pulmonary medicine, volume 22, issue 2, pp. 138-143, 2016.
Z.Q. Meng and Q.X. Zhang. “Effects of dust storm fine particles instillation on oxidative damage in hearts, livers, lungs of rats”. Weisheng Yanjiu, volume 35, pp. 690-693, 2006.
U. Mani, A.K. Prasad, V. Suresh, V. Kumar, K. Lal, R.K. Kanojia, B.P. Chaudhari and R.C. Murthy. “Effect of fly ash inhalation on biochemical and histomorphological changes in rat liver”. Ecotoxicol. Environ. Saf., volume 68, pp. 126-133, 2007.
J.G. Wallenborn K.D. Kovalcik, J.K. McGee, M.S. Landis and U.P. Kodavanti. “Systemic translocation of zinc: kinetics following intratracheal instillation in rats”. Toxicol. Appl. Pharmacol., volume, 234, pp. 25-32, 2009.
P.H. Danielsen, S. Loft, N.R. Jacobsen, K.A. Jensen, H. Autrup, J.L. Ravanat, H. Wallin and P. Moller. “Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter”. Toxicol. Sci., volume 118, pp. 574-585, 2010.
J.A. Bourdon, A.T. Saber, N.R. Jacobsen, K.A. Jensen, A.M. Madsen, J.S. Lamson, H. Wallin, P. Møller, S. Loft, C.L. Yauk and U.B. Vogel. “Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver”. Part. Fibre Toxicol., volume 9, p. 5, 2012.
N.L. Mills, K. Donaldson, P.W. Hadoke, N.A. Boon, W. MacNee, F.R. Cassee, T. Sandström, A. Blomberg and D.E. Newby. “Adverse cardiovascular effects of air pollution”. Nat. Clin. Pract. Cardiovasc. Med., volume 6, pp. 36-44, 2009.
S.E. Manahan. “Toxicologoical chemistry and Biochemistry” (3rd ed.). CRC Boca Raton New York Washington D.C. Pp. 214-224, 2003.
A.K. De. “Environmental chemistry” (7th edn.). Newage international publishers. Pp 112-115, 2010.
S.J. Offor, H.O.C. Mbagwu and O.E. Orisakwe. “Lead Induced hepato-renal damage in male albino rats and effects of activated charcoal”. Front pharmacol. Volume 8, number 107, pp. 1-7, 2017.
O.A. Ojiako, P.C. Chikezie and A.C. Ogbuji. “Histopathological studies of renal and hepatic tissues of hyperglycemic rats administered with traditional herbal formulations”. Int. J. Green Pharm. Volume 9, pp. 184-191, 2015.
American Society for Testing and Materials (ASTM). “Standard Guide for Sampling Strategies for heterogenous wastes” ASTM, D 5956 01, 2001.
J.D. Banchroft, A. Stevens and D.R. Turner. “Theory and practice of histological techniques”. 4th ed. New York, London, San Francisco, Tokyo: Churchil Livingstone, 1996.
World Health Organisation (WHO) “Air quality guidelines for Europe” (2nd ed.) WHO regional publications, European series. Pp 91, 2000
Nigerian Environmental Standard and Regulation Enforcement Agency (NESREA). “Guidelines and standards for environmental protection in Nigeria”, NESREA, Abuja, 2009.
N.A. Akuagwu, E.N. Ejike and A.U. Kalu. “Estimation of air quality in Aba Urban, Nigeria, using the multiple linear Regression Technique”. Journal of Geography, Environment and earth science. International, volume 4, issue 2, pp. 1-6, 2016.
B.L. Karthik, B. Sujith, S.A. Rizwan and M. Sehgal “Characteristics of the ozone pollution and its health effects in India”. Int. J. med. Public Health. Volume 7, issue 1, pp. 56 – 60, 2017.
R. Atkinson, W. Butland, K. Barbara, H. Anderson and H. Ross. “Long-term concentrations of Nitrogen dioxide and mortality: A meta-analysis of cohort studies”. Epidemiology, volume 29, issue 4, pp. 460-472, 2018.
United States Environmental Protection Agency (USEPA). “Integrated Science Assessment for sulphur oxides – Health criteria”, (external Review Draft), 2015.
B. Pandey, A. Madhoolika and S. Siddharth. “Assessment of air pollution around coal mining area: Emphasizing on spatial distributions, seasonal variations principal component analysis”. Atmosphere pollution research, volume 5, pp. 79-86, 2014.
F. Rajaii, A.A. Khaki, A. Khaki, F. Khorshid, N. Borhani, H. Jfraii, H. Haghdust and N. Gheibi. “Histopathologic Effects of Sulfur Dioxide in Mouse Liver Following the Chronic and Acute Exposure”. Journal of Biological Sciences, Vol. 8, issue 7, pp. 1241-1245, 2008
Z. Meng. “Oxidative damage of sulfur dioxide on various organs of mice: Sulfur dioxide is a systemic oxidative damage agent”, Inhalation toxicology, international forum for respiratory research, volume 15, pp. 181-195, 2008.
G. Chen, S. Li, Y. Zhang, W. Zhang, W. Li, X. Wei, Y. He, M.L. Bell, G. Williams, G.B. Marks, B. Jalaludin, M.J. Abramson and Y. Guo. “Effects of ambient PM1, air pollution on daily emergency hospital visits in China: an epidemiological study. Lancet planet Health, volume 1, pp. 221-229, 2017.
Y. Xing, Y. Xu, M. Shi and Y. Lian. “The impact of PM2.5 on the human respiratory system”. Journal of Thoracic Disease, volume 8, issue 1 pp. 69-74, 2016.
A. Zwozdziak, I. Sowka, E. Willac-Janc, J. Zwozdziak, K. Kwiecinska and W. Balinsk-Miskiewicz. “Influence of PM1 and PM2.5 on lung function parameters in healthy school children - a panel study”. Environ. Sci. Pollut Res. Volume 23, pp. 892 -901, 2016.
Z. Zheng, X. Zhang, J. Wang, S. Rajagopalan, Q. Sun and K. Zhang. “Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models”, Journal of hepatology, volume 63, issue 6, pp. 1397-1404, 2015.
T. Kapwata, B. Language, S. Piketh and C.Y. Wright. “Variation of Indoor particulate matter concentrations and association with indoor/outdoor temperature: A case study in rural Limpopo, south Africa”. Atmosphere, volume 9, number 124, pp. 1-4, 2018.
B. Seibokuro, T.C.N. Angaye and O. Konmeze. “Assessment of the fate and intensity of particulate matter associated with playgrounds in traffic-congested areas of Yenagoa metropolis , Nigeria”. MOJ Toxicol, volume 4, issue 6, pp. 432-438, 2018.
Air Quality Expert Group (AQEG). “Particulate matter in the Uk: Summary’. Defra. London. Pp 1-30, 2005.
V.K. Nartey, J.N. Nanor and R.K. Klake. “Effects of quarry activities on some selected communities in the lower Manya Krobo district of the Eastern region of Ghana”. Atmospheric and climate sciences, volume 2, pp. 362-372, 2012.
N. Koleli and A. Demir. “Chromite. Environmental materials and waste’. Pp. 1-7, 2016.
S.E. Orr and C.C. Bridges. “Chronic Kidney Disease and Exposure to Nephrotoxic Metals”, Int. J. Mol. Sci., volume 18, issue 5, pp. 1039, 2017.
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