Anticonvulsant Activity of Majoon Najah Against PTZ Induced Seizure in Swiss Albino Mice

Authors

  • Zeba Afrin Central Council for Research in Unani Medicine Headquarters, Janakpuri, New Delhi, India
  • Aisha Siddiqui Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India
  • M.A Jafri Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India
  • Divya Vohora Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi
  • M Asif Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India

Keywords:

Majoon Najah, anticonvulsant, pentylenetetrazole, mice

Abstract

Objective: To compare the anticonvulsant activity of Majoon Najah, its hydroalcoholc extract and granular form through Pentylenetetrazole (PTZ) test in swiss albino mice. Material & Methods: Majoon Najah (MN), its hydroalcoholic extract (HEMN) and granular form (GMN) were tested for anticonvulsant activity using Pentylenetetrazole (PTZ) test animal model. To evaluate the effect of test drugs on motor co-ordination, muscle co-ordination test by rotarod was carried out. Results: It was found that MN (p<0.01), HEMN and GMN (p<0.001) significantly increased the latency of myoclonic jerks and clonic generalized seizures when compared with control. The findings of the rotarod test suggest that the test drugs (MN, HEMN and GMN) did not produced any motor inco-ordination. So MN, HEMN and GMN are safer than conventional antiepileptic drugs. Conclusion: It can be concluded from the experiment performed that Majoon Najah, its hydoalcoholic extract and granular form possess significant anticonvulsant activity.

 

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Published

2018-12-31

How to Cite

[1]
Z. Afrin, A. Siddiqui, M. Jafri, D. Vohora, and M. Asif, “Anticonvulsant Activity of Majoon Najah Against PTZ Induced Seizure in Swiss Albino Mice”, Int. J. Sci. Res. Biol. Sci., vol. 5, no. 6, pp. 170–179, Dec. 2018.

Issue

Vol. 5 No. 6 (2018): December Edition

Section

Research Article

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