Evaluation of Pharmacological Activities of the Leaf Extracts of Antidesma menasu Miq.
Keywords:
Antidesma menasu, anti-inflammatory, analgesic, antimicrobialAbstract
Antidesma menasu is a folklore plant known for its anti-inflammatory and analgesic properties. Folklore practitioners use the leaves of this plant for swelling of body parts, lower back pains, arthritis in humans and swelling of shoulders and udders in animals. Development of a new drug requires pre-clinical studies of crude extracts on animal models. The objective of this study is to screen the drug for its pharmacological activities. Present study reveals anti-microbial, anti-inflammatory and analgesic properties of aqueous and ethanol extracts of Antidesma menasu. It also includes toxicity study, for screening the crude extracts for any adverse effects on animals and comparison of the effectiveness of the drug in corresponding solvents.
References
Fox J.C., Fitzgerald M.F, ?The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD?, Curr Open Pharmacol, Vol 9, Issue 3, pp 231-242, 2009.
Seema Tripathy, ?Importance of plants and animals in medicine?, J. Exp. Zool.India,Vol 18, Issue 2, pp 1-12, 2015.
Dinesh K Badyal, Chetna Desai, ?Animal use in Pharmacology education and research: The changing scenario?, Indian Journal of Pharmacology, Vol 46, Issue 3, pp 257-265, 2014.
Sangha Bijekar, M C Gayathri, ?Ethanomedical properties of Euphorbiaceae family- A comprehensive review?, International Journal of Phytomedicine, Vol 6, Issue 2, pp 144-156, 2014.
Sunil Kumar, Rashmi Malhotra, Dinesh, ?Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities?, Pharmacognosy Review, Vol 4, Issue 7, pp 58-61, 2010.
Bonum Srinivasa Reddy, Nadendla Rama Rao, Vijayapandi Pandy, ?Phytochemical, Pharmacological and biological profiles of Tragia species (Family:Euphorbiaceae)?, African Journal of Traditional, Complementary and Alternative Medicines, Vol 14, Issue 3, pp 105-112, 2017.
Battu Ganga Rao, Bobbili Sasi Rekha, Devarakonda Ramadevi, Battu Heera, ?Phytochemical and pharmacological studies on Jatropha gossypiifolia?, Journal of Global Trends in Pharmaceutical Sciences, Vol 9, Issue 1, pp 4978-4986, 2018.
Deepti Sisodiya, Pragya Shrivastava, ?A review on pharmacognostical and pharmacological perspective of Euphorbia thymifolia L.?, Asian Journal of Pharmaceutical Education and Research, Vol 6, Issue 1, pp 31-39, 2017.
Shi Qing, Xiao-Hui Su, Hiromasa Kiyota, ?Chemical and Pharmacological research of the plants in genus Euphorbia?, Chemical reviews, Vol 108, Issue 10, pp 4295-4327, 2008.
Norsharina Ismail, Nur Hanish Azmi, Siti Nurulhuda Mastuki, Norzalina Saad, ?Antidesma montanum: Biochemistry and Bioactive compounds?, Wild fruits: Composition, Nutritional value and Products, pp 359-365, 2019.
Arathi Krishnan, Ravi Mundugaru, Suma V Mallya, Sridhar Bairy, ?Experimental evaluation of Analgesic and anti-inflammatory potential of leaves of Antidesma acidum on Wistar albino rats?, Journal of Biological and Scientific Opinion, Vol 2, Issue 1, pp 1-3, 2014.
Lintang Kautsar, Panal Sitorus, Aminah Dalimunthe, ?Anti-inflammatory activity of ethanol and fraction of Buni leaves (Antidesma bunnies L) on White rat in Carrageenan induced paw inflammation?, Asian Journal of Pharmaceutical research and Development, Vol 7, Issue 5, pp 01-05, 2019.
Arun Prabhakar Sithara, Ravi M, Suma Mallya, Sudhakar, Sridhar Bairy, Srikanth P, Ravishankar, ?Experimental evaluation of analgesic and anti-inflammatory potential of leaves of Antidesmamenasu on wistar albino rats?, International Journal of Pharmacology and Clinical Sciences, Vol 9, Issue 4, pp 105-112, 2013.
Neha Sharma, D S Rathore, ?Antibacterial effects of Citrus limon peel extract on human pathogenic bacteria with special reference to Urinary Tract Infection?, International Journal of Scientific Research in Biological Sciences, Vol 5, Issue 2, pp 14-17, 2018.
Dhanya P, Rama Bhat P, Muddaiah Siddaraju, ?Antimicrobial activity of leaf extracts of Antidesma menasu Miq.?, International Journal of Scientific Research and Publications, Vol 7, Issue 6, pp 328-331, 2017.
Sabuha Shafi, Nahida Tabassum, ?Phytochemical and acute toxicity studying of Euphorbia japonicaseed extract in Albino mice?, International Journal of Research in Pharmaceutical and Biomedical Sciences, Vol 4, Issue 1, pp 202-205, 2013.
Winter CA, Ristey EA, Nuss GW, ?Carragenaan-induced oedema in the hind paw of the rats as an assay for anti-inflammatory drugs?, Proc Soc Exp Biol Med, Vol 111, 544-550, 1962.
Ashok Kumar Gupta, Devraj Parasar, Amin Sagar, Vikas Choudhary, Bhupinder Singh Chopra, Renu Garg, Ashish Neeraj Khatri, ?Analgesic and Anti-inflammatory properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Oedema in Mice?, 2015, http://doi.org/10.1371/journal.pone.0135558.
F. Mustaffa, J Indurkar, S.M Mansor, ?Analgesic activity, toxicity study and phytochemical screening of standardized Cinnomuminers leaves methanolic extract?, Pharmacognosy Research, Vol 2, Issue 2, pp 76-81, 2010.
Hunskaar S, Fasmer OB, Hole K, ?Formalin test in mice, a useful technique for evaluating mild analgesics?, J Neurosci Methods, Vol 4, pp 69-76, 1985.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors contributing to this journal agree to publish their articles under the Creative Commons Attribution 4.0 International License, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit and that in the event of reuse or distribution, the terms of this license are made clear.
Download Article Template
