Determination of Anti-Inflammatory Activity of Coumarin Compounds of Coldenia Procumbens Linn

Authors

  • S. Babu Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi Thanjavur, India
  • V. Ambikapathy Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi Thanjavur, India
  • A. Panneerselvam Department of Botany and Microbiology, A.V.V.M. Sri Pushpam College, Poondi Thanjavur, India

Keywords:

C.procumbens, coumarin, BSA, Egg albumin

Abstract

In the present study, invitro anti-inflammatory activity was tested using coumarin compound of C.procumbens. Coumarins are a group of polyphenolic compounds isolated by TLC method from C.procumbens plant extract. In anti-inflammation study, the methanolic extract showed high percentage of inhibition observed in egg albumin denaturation studies was 78.8% of 0.8µg/ml concentration of coumarin compounds where as compared to standard drug Diclofenac sodium 74.8%. While, bovine serum albumin denaturation assay was 67.8 % of 0.8 µg/ml concentration when compared to other concentration of coumarin compounds. The results were discussed.

 

References

Amri, O., Zekhnini, A., Bouhaimi, A., Tahrouch, S. and Hatimi, A., (2018). Anti-inflammatory activity of methanolic extract from Pistacia atlantica Desf. leaves. Pharmacog J.; 10(1):71-6.

Chatterjee P, Chanda S, Dev P., and Bhattacharya S. (2012). Evaluation of anti-inflammatory effects of green tea and black tea: a comparative in vitro study. Journal of Advanced Pharmaceutical Technology and Research.; 3(2):136-138.

Chopra, R.N., Nayar, S.L. and Chopra, I.C., (1956). Glossary of Indian Medicinal Plants. CSIR, New Delhi.

Cox, P.A. and Balick, M.J., (1994). The ethnobotanical approach to drug discovery. Scientific American.; 270(6):60-65.

Das, S.N. and Chatterjee, S., (1995). Long term toxicity study of ART‐400. Indian Indg Med; 16 (2): 117‐123

Dinarello C., (2010). Anti-inflammatory Agents: Present and Future. Cell; 140: 935–950.

Heendeniya, SN., Ratnasooriya WD. and Pathirana, RN., (2018). In vitro investigation of anti-inflammatory activity and evaluation of phytochemical profile of Syzygium caryophyllatum. J. of Pharmaco. and Phytochem.; 7(1): 1759-1763.

Kennedy and Wightman. (2011). Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain Function1. Advance in. Nutrition.; 2:32-50.

Kiritikar, K.R. and Basu, B.D., (1980). Indian Medicinal Plants, V. 1-4. Bishen Singh Mahendra Pal Singh, Dehra Dun.

Leelaprakash G. and Mohan Dass S., (2011). “Invitro Antiinflammatory activity of Methanol extract of Enicostemma Axillare. Int. J. Drug Dev. and Res., 3(3): 189-196.

Medzhitov R., (2010). Inflammation: New Adventures of an Old Flame. Cell; 140: 771–776.

Mizushima Y. and Kobayashi M., (1968). Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins. Pharmacy and Pharmacology.; 20:169-73.

Mizushima Y., (1966). Screening test for anti-rheumatic drugs. Lancet.; 2:443-448.

Muratovic, S. Osmanovic, A., Veljovic, E., Dzudzevic-Cancar, H., Duric, K., Niksic, H. and Zavrsnik, (2013). Evaluation of purity of some coumarin derivatives by melting point measurements, TLC and scanning densitometry. Bulletin of the Chemists and Technologists of Bosnia and Herzegovina.: 41: 15-19

Nyiredy, S. (2001). Planar Chromatography a Retrospective View for the Third Millenium. 36-42. Springer Scientific Publisher, Budapest.

Rahman, H., Eswaraiah, M.C. and Dutta, A.M., (2015). In-vitro antiinflammatory and anti-arthritic activity of Oriza sativa Var. Joha Rice (An Aromatic Indigenous Rice of Assam). American Eurasian Journal of Agricultural and Environmental Sciences.; 15(1):115-121.

Saso, L, Valentini, G, Casini, ML, Grippa, E, Gatto, MT. and Silvestrini, B. (2001). Inhibition of heat-induced denaturation of nonsteroidal antiinflammatry drugs (NSAIDs): pharmacological implications. Archives of Pharma. Research.; 24(2):150-158.

Umapathy, E., Ndebia, E.J., Meeme, A., Adam, B., Menziura, P., Nkeh-Chungag, B.N. and Iputo, J.E., (2010). An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation. J.of Medicinal Plant Res.; 4 (5) 789-795.

Vane, J.R. and Botting, R.M., (1995). New insights into the mode of action of anti-inflammatory drugs. Inflammation Res.; 44 (1) 1-10.

Williams L.A., O'Connar, A., Latore, L., Dennis, O., Ringer, S., Whittaker, J.A., Conrad, J., Vogler, B., Rosner, H. and Kraus, W., (2008). The in vitro anti-denaturation effects induced by natural products and non-steroidal compounds in heat treated (immunogenic) bovine serum albumin is proposed as a screening assay for the detection of anti-inflammatory compounds, without the use of animals, in the early stages of the drug discovery process. West Indian Med J. ;57(4):327-31.

Zhao HL, Harding SV, Marinangeli CP, Kim YS. and Jones PJ., (2008). Hypocholesterolemic and anti-obesity effects of saponins from Platycodon grandiflorum in hamsters fed atherogenic diets. Journal of Food Science.; 73(8):195-200.

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Published

2018-10-31

How to Cite

[1]
S. Babu, V. Ambikapathy, and A. Panneerselvam, “Determination of Anti-Inflammatory Activity of Coumarin Compounds of Coldenia Procumbens Linn”, Int. J. Sci. Res. Biol. Sci., vol. 5, no. 5, pp. 77–79, Oct. 2018.

Issue

Vol. 5 No. 5 (2018): October Edition

Section

Research Article

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